You can mix Ketamine with anti-depressants. At the clinics, they say you stay on your anti-depressants while having Ketamine therapy.
Ibogaine: there are some places that offer it legally depending on the country. You should only do it with a real Shaman as it's very strong. They use it for heroin addiction. It apparently makes you review your life and see that you could make different choices.
I tried it at home - I do not recommend that under any circumstances. I think you might need to detox from any medication first (check the guidelines) and also it is not suitable for anyone with heart conditions.
I have personally only tried Ayahuasca which was helpful for me, she took away my self-hatred, but not my depression.