I've done shrooms once, 25i once, and LSD probably about a dozen times. Definitely worth having the experience, I'd say. Also, a couple times when I took LSD while really depressed, it yanked me out of the depressive episode and made me feel good for about a week afterwards (sort of an LSD "afterglow"). But last time I took it, I took a little too much and was suicidal, and I had a bad trip. But keep the dose low (100-150 ug) and don't do it when you're in a really depressed mood and you'll be fine.