symphony

symphony

surving hour-by-hour
Mar 12, 2022
779
"Treatment resistant" here refers to someone who has tried multiple treatments (especially medications) for mental illness but has not seen improvement. (It is not the same as refusing or resisting treatment.)

I have treatment-resistant depression. I've tried just about everything under the sun. Starting this thread to see if I can connect with anyone else in a similar situation. I know well it's a shitty place to be in.
 
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A

Amor

Member
Sep 25, 2022
39
I don't believe in recovery at all, but also no treatment on earth will ever work if the environment the patient is in doesn't change, this includes the people around them too. And this is obviously impossible. And even if it were possible, I think some of us are way too damaged to be healed. I really don't believe in recovery. There just comes a point where trauma or illness cements itself in every part of you and there's nothing to do. It's hopeless.
 
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Capsaicin78

Capsaicin78

Full time failure
May 4, 2022
238
I don't believe in recovery at all, but also no treatment on earth will ever work if the environment the patient is in doesn't change, this includes the people around them too. And this is obviously impossible. And even if it were possible, I think some of us are way too damaged to be healed. I really don't believe in recovery. There just comes a point where trauma or illness cements itself in every part of you and there's nothing to do. It's hopeless.
Wrong subforum with this attitude buddy.


"Treatment resistant" here refers to someone who has tried multiple treatments (especially medications) for mental illness but has not seen improvement. (It is not the same as refusing or resisting treatment.)

I have treatment-resistant depression. I've tried just about everything under the sun. Starting this thread to see if I can connect with anyone else in a similar situation. I know well it's a shitty place to be in.
same here. Have tried out regular therapy + antidepressants and it didnt work.
You tried ketamine or "regular" psychedelics like psylocibin yet?
It seems to help 70 - 80 % with TRD.
 
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Lawliet

Lawliet

b a n g
Sep 15, 2020
349
i've been on medications for about 15 years, i'm resistant but i also get acclimated to the drugs pretty quickly. i do counseling twice a week. i've done almost everything except ECT, including ketamine, long term hospitalizations, and more ancient drugs like lithium. they have me trying out this brand new medication now.

my mental diagnoses are BPD, PTSD, depression, and anxiety. i'm sorry things haven't worked out for you.
 
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A

AnonymousS

Specialist
Sep 11, 2021
303
"Treatment resistant" here refers to someone who has tried multiple treatments (especially medications) for mental illness but has not seen improvement. (It is not the same as refusing or resisting treatment.)

I have treatment-resistant depression. I've tried just about everything under the sun. Starting this thread to see if I can connect with anyone else in a similar situation. I know well it's a shitty place to be in.
Yes although i suppose treatment resistance for some people might be fairly complex. I have had chronic recurrent depression since 1999-2000. Like many others as the years have gone on the depression became much more severe, leading to multiple suicide attempts. Been on many medications, a few TCA' s, most of the SSRI's, at least one MAOI, and combinations with anti-psychotics, also lithium. Unfortunately not much in terms of psychotherapy, CTB did work for awhile when my illness was milder, however after some time i became too ill for it to have an effect. I have had ECT on two different occasions, both times it helped however life stressors i think became too much, and i think the brain can only handle so much. Later on was told i had PTSD also, my current medication keeps my head above water-so to speak-but i feel like a zombie. I also have chronic fatigue which doesn't help, so my days consist of basically going through the motions. If i had access to a peaceful method, or if i felt confident that i wouldn't screw things up, i would disappear. I feel like my existence is no longer worth it, and i also have nothing to offer society. I think there are a lot of us about, who have a deep and chronic severe illness. I wish mental health got the proper support and funding other medical issues do.
 
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A

akirat9

エクトリアン
Sep 23, 2022
386
yeah me.
what am i to do ? without sn just rot away
 
RedHarlequin

RedHarlequin

Mage
Jul 8, 2018
530
I am/ was. I tried around 20 meds, 4 years of cbt, ect (traumatizing stuff), hospital stay at a good hospital for 3 months, hospital stay at a better hospital for 6 months, got my N stacked up, gave my stuff away, wrote my letters. Told my mom and best friends that Ibwas killing myself and that i wanted them to be there for my last moments, they agreed after a period of schock. They told me they wanted whats best for me.
The Depression comes back every couple of months so I won't forget what it's like and so that I would update my N sources :D even though it being helpless and wanting to die is no walk in the park, I do believe it makes a better person out of me (not for the ones close to me though), and as im warking in the field, people seem to like my capability of showing empathy
 
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stilhavinightmares

stilhavinightmares

Warlock
Oct 13, 2022
735
Hi. My depression is treatment resistant also. I've tried so many meds, individual therapies, group therapies, have been inpatient over a dozen times. I was going to ctb this week but I couldn't get myself to do it so maybe I'm not ready. I just don't know what is left; I'm wondering about ketamine but idk if it's worth staying to try. I'm exhausted and the pain is excruciating.
 
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SectOfValtiel

SectOfValtiel

Attendant of God
Nov 7, 2022
217
yeah, ive been in therapy for 4 years and tried at least a dozen antidepressants, nothing made a noticeable difference or at least not for long before trailing off and being completely ineffective
but ive also been diagnosed with a personality disorder so honestly that might have a lot to do with it
and someone earlier said if your environment doesnt change your mood wont, theyre definitely right
i dont really have the means to change my environment- whether that be in the literal sense as in my living space, or as in the people you surround yourself with
i dont have a choice so

but i just started DBT for the first time so
at least its something different, something i havent tried before
 
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stilhavinightmares

stilhavinightmares

Warlock
Oct 13, 2022
735
yeah, ive been in therapy for 4 years and tried at least a dozen antidepressants, nothing made a noticeable difference or at least not for long before trailing off and being completely ineffective
but ive also been diagnosed with a personality disorder so honestly that might have a lot to do with it
and someone earlier said if your environment doesnt change your mood wont, theyre definitely right
i dont really have the means to change my environment- whether that be in the literal sense as in my living space, or as in the people you surround yourself with
i dont have a choice so

but i just started DBT for the first time so
at least its something different, something i havent tried before
I hope you find DBT helpful! It was for me. Not enough to make me want to live but it definitely helps with reducing suffering, and creating a life worth living for a LOT of people.
 
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SectOfValtiel

SectOfValtiel

Attendant of God
Nov 7, 2022
217
I hope you find DBT helpful! It was for me. Not enough to make me want to live but it definitely helps with reducing suffering, and creating a life worth living for a LOT of people.
any amount of success would be 10x better than what ive experienced tbh
thanks, that might not sound the most reassuring but it is to me so i appreciate the words
 
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Celerity

Celerity

shape without form, shade without colour
Jan 24, 2021
2,733
Yes. I used to feel like a freak of nature for this, but just check out how many of these "antidepressants" work better than placebo and you may cut yourself some slack. One meta-analysis (large analysis of research studies) estimated the placebo effect to be commensurate with at least 75% of the observed effect from the antidepressants they included in the study.

75% - 75% owed to what you could get from a sugar pill and a prayer.

The links I have shared here below are about a study yielding even higher numbers - 80%+.


 
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LookingOverTheEdge

LookingOverTheEdge

Hello Darkness my old friend
Jul 13, 2020
356
I strongly suspect that I will turn out to be. We shall see, or at least we will if I ever actually get anywhere trying to get treatment. The system in my country is a broken mess in all honesty.
 
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LookingforAnswers

LookingforAnswers

Student
Mar 15, 2022
113
🙋🏼‍♂️ this guy.

Tried 5-6 diff antidepressants and antipsychotics, mood stabilizer.

Did accelerated tms.

Am now trying spravato (ketamine). Nothing has seemed to help. Prior i was normal, happy, social, etc etc.
 
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F

ferny

Member
Dec 14, 2021
16
Yeah, but personally i feel like it's because something else is going on in brain, i just don't know what. At first I was told that an autism diagnosis could explain why nothing works for me, now I'm in the process of getting an ADHD diagnosis. Idk, in the end i just find it frustrating. Even though I'm young, I've somewhat accepted that both depression and addictive behaviors might be an issue for me forever.
 
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stilhavinightmares

stilhavinightmares

Warlock
Oct 13, 2022
735
🙋🏼‍♂️ this guy.

Tried 5-6 diff antidepressants and antipsychotics, mood stabilizer.

Did accelerated tms.

Am now trying spravato (ketamine). Nothing has seemed to help. Prior i was normal, happy, social, etc etc.
If you don't mind, would you share your experience with spravato? I've been considering trying it if possible
 
LookingforAnswers

LookingforAnswers

Student
Mar 15, 2022
113
If you don't mind, would you share your experience with spravato? I've been considering trying it if possible
So im 5 weeks in. It gets you fucked up pretty quickly from spray (within 10 minutes). You have dissassociaction but not to the extent you arent aware of reality. As for my thoughts i cant say it has really done much for my suicidality, but maybe im more physically capable. It is somewhat enjoyable if you like getting fucked up, but as for treatment of depression i cant say its done too much unfortunately.

That being said just like any other drug experiences are going to differ so if you insurance covers it why not try it. Out of every antidepressant ive taken this has no side effects. Every other one ive had insomnia, bloating, extraparamital etc. this outside of the 2 hours you are out of it nothing after. You get high like 10 mins in prob lasts like an hr and you are loopy the last hr
 
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Rainy_days

Rainy_days

Experienced
Dec 21, 2022
261
First started trying different treatments ~22 years ago. Still have crippling depression and social anxiety, so I would say, yes.
 
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stilhavinightmares

stilhavinightmares

Warlock
Oct 13, 2022
735
So im 5 weeks in. It gets you fucked up pretty quickly from spray (within 10 minutes). You have dissassociaction but not to the extent you arent aware of reality. As for my thoughts i cant say it has really done much for my suicidality, but maybe im more physically capable. It is somewhat enjoyable if you like getting fucked up, but as for treatment of depression i cant say its done too much unfortunately.

That being said just like any other drug experiences are going to differ so if you insurance covers it why not try it. Out of every antidepressant ive taken this has no side effects. Every other one ive had insomnia, bloating, extraparamital etc. this outside of the 2 hours you are out of it nothing after. You get high like 10 mins in prob lasts like an hr and you are loopy the last hr
Thanks so much for sharing all this!!! Sorry it hasn't helped with the depression or suicidality much (yet?). I definitely would prefer getting fucked up and it not working than numerous med trials with side effects and them not working (which is obviously what most of our pasts are). 😂
 
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H

Hollowman

Empty
Dec 14, 2021
1,329
If their "treatments" were more effective there'd be less "resistant" people. It's just another quack label. Those people need to get real jobs.
 
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wait.what

wait.what

no really, what?
Aug 14, 2020
985
I've tried every class of antidepressants except the MAOI inhibitors. The total drug washout scares me. I also don't want to be banned from more food than I already am. (Starting an elimination diet.) I've done every procedure except ECT. I begged for it multiple times, but the doc said I was a poor candidate for it. I guess it doesn't help long-standing depression much. I've done ketamine, both Spravato and IV infusions. IV ketamine and TMS (transcranial magnetic stimulation) at the same time helped for some weeks, but it's an exhausting regimen, and stupid expensive.

As for therapy, I've done CBT, DBT, ACT, biofeedback, hypnosis, psychodrama, dream journaling, gratitude journaling, mindfulness, EMDR, group therapy, hospitalizations, 12 step groups, and whatever it was my childhood and teenage years therapists did. I've talked to both full and empty chairs. I've petted a lot of therapy dogs.

I do not have BPD. Everyone assumes I do, because that's what chronic suicidality and treatment-resistant depression is supposed to be. I think personality disorders in general are kind of hogwash. People seem to agree there are three major subtypes, and people with Cluster A personality disorders probably are usefully distinct from people with Cluster C. As for whether there are ten or fourteen or twenty-two of the things, and what counts as a disorder, and who is put in one box and who goes in another, there's more subjectivity than I would like. Diagnoses are not all harmless, either. Personality disorders can be used as evidence of the unfitness of a parent to have custody of a child. They can mean the difference between a diversion program and prison. Cluster A personality disorders, as well as BPD, are the ones most likely to be unwanted labels. I was diagnosed with BPD at 18, and the docs told my parents that you basically had to throw away the whole kid. I was always going to need intensive therapy, I was quite likely to kill myself, and there were no cures or even treatments. This was before DBT, and BPD patients were thought to be hopeless. A lot of therapists refused to see patients with that label. They were considered too much work for no payoff. There was no compassion.

I don't even have BPD. I was a traumatized and poorly-socialized adolescent. And frankly, they pissed me off. I figured they had it coming. :p According to one doc, I do have a personality disorder, though, and it's my very favorite psychiatric condition in my extensive collection: "Personality Disorder Not Otherwise Specified." Out of the foggy haze of personality disorders, the doc has pulled the foggiest of them all. It is a rare honor, and I will bear it with pride.

Why am I talking about that? Who cares about my ridiculous diagnosis. :p

Anyway, I seem not to technically have a mental condition at all. I have a number of physical conditions that have psychiatric features. I definitely have Pyrrole Disorder and a pretty bad intolerance to yeast. I strongly suspect that I also have a mild form of Congenital Adrenal Hyperplasia. I'm supposed to follow this ultra-restrictive elimination diet, and this will help, I'm told. I kept putting it off because it sounds awful, but I'm finally starting it, because what I've been doing lately isn't working.
 
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Heartaches

Heartaches

Apologizing for my life and ever entering yours
May 6, 2021
261
I haven't had as extensive or diverse treatments as others, but I'm pretty confident SSRIs don't work for me. I absolutely hate them, but my psychiatrists won't give me any other type of medications because they claim my depression "is not as bad" as I make it out to be.

For therapy, I've mostly worked with CBT, which has been the one I've fared best results with, but still very inconsistent. I've also tried positive therapy, a bit of mindfulness and one centered around breathing (don't know what it's called). They haven't fared good results.

I would like to try other medications or alternative methods, but I'm also afraid. I'm not someone who gets sick easily under normal circumstances, but meds can make me fall to my knees if I'm prescribed very strong or several at the same time. I don't have any allergies nor any physical or immunological diseases, but my body can have very extreme reactions; never to the point of being taken to emergency, but still pretty bad. So I have to be very aware, which makes me paranoid sometimes.
 
symphony

symphony

surving hour-by-hour
Mar 12, 2022
779
This thread has blown up since I was last online. Thank you all for sharing your stories. I feel less alone reading through this.
 
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V

Veffexorline1970

Member
Sep 1, 2021
6
I think I've been on 6 different antidepressants since age 16.. none of them have felt like they've truly helped me? I've just come off of venlafaxine, and I'm trying a new one called vortioxetine. I've also been off/on CBT for years but I really truly feel beyond help at some points.
Don't want to be too much of a Debbie downer, but it does feel like theres so much money in antidepressants that there isn't any point in looking for new ones that could help us that are treatment resistant. that, and it also feels like we really just don't fucking know whether they work? the clinical studies they do, they purposefully redact and edit their studies so their drug looks better than the placebo.
it's really fucking disheartening.
 
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R

Regen

I stay in my power
Aug 20, 2020
403
I am sorry for your pain. I struggle with depression too since I was a child.

I tried many medication. And I feel better with medication, but I never was without depression.

My plan for 2023 is to visit a special ambulant hospital only for chronic depression to see what they mean I should try with medication. But I dont want to try EDC or Lithium or mao-blocker. So I am not very hopeful with this plan.

Second I want to try Vitamin D, my level of Vitamin D is too low.

Third I want to visit another 12-step-meeting again. And I want to try to do more in the steps.

I dont know how life feel without depression. I have no Hope being without depression at some point. But I hope I can find a way to cope much better. And I hope I can learn to not critism me for having depression.

I send you love, you are not alone.
 
NoLightRemains

NoLightRemains

I found my light again. Namu Amida Butsu
Sep 26, 2021
374
I have treatment resistant depression. I've done multiple anti-depressants, mood stabilizers, and ketamine all within the last 2-3 years. I have basically given up hope that medications can fix me long term. I recently got off a new medication that did nothing but make me anxious and give me energy to fixate on suicide. After a lot of misses, I started lithium a couple weeks ago and it has reduced my suicidal thoughts a bit. They never fully go away, but I'm obsessing less over them for now. My emotions are less overwhelming which is a nice change. We'll see how long this lasts.
 
stilhavinightmares

stilhavinightmares

Warlock
Oct 13, 2022
735
I have treatment resistant depression. I've done multiple anti-depressants, mood stabilizers, and ketamine all within the last 2-3 years. I have basically given up hope that medications can fix me long term. I recently got off a new medication that did nothing but make me anxious and give me energy to fixate on suicide. After a lot of misses, I started lithium a couple weeks ago and it has reduced my suicidal thoughts a bit. They never fully go away, but I'm obsessing less over them for now. My emotions are less overwhelming which is a nice change. We'll see how long this lasts.
I'm glad the lithium is giving you some reprieve. If you don't mind me asking, what was the med that gave you anxiety and energy? I've experienced that with a few before.
 
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girlsboysthems

girlsboysthems

no i dont have a gun
Dec 19, 2022
418
same here, multiple meds of different type, hospitalization, talk therapy (psychodynamic), now starting group therapy. as far as im concerned ACT is not available in my country, esketamine is not even an option. talk therapy helped the most to be honest, but still not the way i desired it.
 
NoLightRemains

NoLightRemains

I found my light again. Namu Amida Butsu
Sep 26, 2021
374
I'm glad the lithium is giving you some reprieve. If you don't mind me asking, what was the med that gave you anxiety and energy? I've experienced that with a few before.
A relatively newer medication called Auvelity. (Brand name)
 

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